Thursday, June 30, 2005

Celebrity Height Facts

Find Out How Tall a Famous Person Is

Google will be glad to tell you the height of your favorite celebrity.

If you put height or tall in a search with a celebrity, google will attempt to tell you how tall that person is.

google: paris hilton tall

google: tom cruise height

Contact your favorite celebrities - receive free autographed photos!

Write to your favorite movie stars!

Movie Posters & Memorabilia

Talent Agent MegaBook - Find an agent today!

Thursday, June 16, 2005

State Motto

In case you don't know your state motto, here is a quick reference.


Alabama - Hell Yes, We Have Electricity.

Alaska - 11,623 Eskimos Can't Be Wrong!

Arizona - But It's A Dry Heat.

Arkansas - Literacy Ain't Everything.

California - By 30, Our Women Have More Plastic Than Your Honda.

Colorado - If You Don't Ski, Don't Bother.

Connecticut - Like Massachusetts, Only The Kennedy's Don't Own It Yet.

Delaware - We Really Do Like The Chemicals In Our Water.

Florida - Ask Us About Our Grandchildren.

Georgia - We Put The Fun In Fundamentalist Extremism.

Hawaii - Haka Tiki Mou Sha'ami Leeki Toru (Death To Mainland Scum, Leave Your Money)

Idaho - More Than Just Potatoes... Well, Okay, We're Not, But The Potatoes Sure Are Real Good

Illinois - Please, Don't Pronounce the "S"

Indiana - 2 Billion Years Tidal Wave Free

Iowa - We Do Amazing Things With Corn

Kansas -First Of The Rectangle States

Kentucky - Five Million People; Fifteen Last Names

Louisiana - We're Not ALL Drunk Cajun Wackos, But That's Our Tourism Campaign.

Maine - We're Really Cold, But We Have Cheap Lobster

Maryland - If You Can Dream It, We Can Tax It

Massachusetts - Our Taxes Are Lower Than Sweden's

Michigan - First Line Of Defense From The Canadians

Minnesota - 10,000 Lakes...And 10,000,000,000,000 Mosquitoes

Mississippi - Come And Feel Better About Your Own State

Missouri - Your Federal Flood Relief Tax Dollars At Work

Montana - Land Of The Big Sky, The Unabomber, Right-wing Crazies, and Very Little Else.

Nebraska - Ask About Our State Motto Contest

Nevada - Hookers and Poker!

New Hampshire - Go Away And Leave Us Alone

New Jersey - You Want A F##$%##! Motto? I Got Yer F##$%##! Motto Right here!

New Mexico - Lizards Make Excellent Pets

New York - You Have The Right To Remain Silent, You Have The Right To An Attorney...

North Carolina - Tobacco Is A Vegetable

North Dakota - We Really Are One Of The 50 States!

Ohio - At Least We're Not Michigan

Oklahoma - Like The Play, But No Singing

Oregon - Spotted Owl...It's What's For Dinner

Pennsylvania - Cook With Coal

Rhode Island - We're Not REALLY An Island

South Carolina - Remember The Civil War? Well, We Didn't Actually Surrender Yet

South Dakota - Closer Than North Dakota

Tennessee - The Edyoocashun State

Texas - Se Hablo Ingles

Utah - Our Jesus Is Better Than Your Jesus

Vermont - Ay, Yep

Virginia - Who Says Government Stiffs And Slackjaw Yokels Don't Mix?

Washington - We have more rain than you do

West Virginia - One Big Happy Family...Really!

Wisconsin - Come Cut The Cheese!

Wyoming - Where Men Are Men... And The Sheep Are Scared

Monday, June 13, 2005

"If" Rudyard Kipling


If you can keep your head when all about you
Are losing theirs and blaming it on you;
If you can trust yourself when all men doubt you,
But make allowance for their doubting too;
If you can wait and not be tired by waiting,
Or, being lied about, don't deal in lies,
Or, being hated, don't give way to hating,
And yet don't look too good, nor talk too wise;

If you can dream - and not make dreams your master;
If you can think - and not make thoughts your aim;
If you can meet with triumph and disaster
And treat those two imposters just the same;
If you can bear to hear the truth you've spoken
Twisted by knaves to make a trap for fools,
Or watch the things you gave your life to broken,
And stoop and build 'em up with wornout tools;

If you can make one heap of all your winnings
And risk it on one turn of pitch-and-toss,
And lose, and start again at your beginnings
And never breath a word about your loss;
If you can force your heart and nerve and sinew
To serve your turn long after they are gone,
And so hold on when there is nothing in you
Except the Will which says to them: "Hold on";

If you can talk with crowds and keep your virtue,
Or walk with kings - nor lose the common touch;
If neither foes nor loving friends can hurt you;
If all men count with you, but none too much;
If you can fill the unforgiving minute
With sixty seconds' worth of distance run -
Yours is the Earth and everything that's in it,
And - which is more - you'll be a Man my son!

Golden Gate Bridge - San Francisco

Golden Gate Bridge - San Francisco

Originally uploaded by Kymbrla.
Postcard shot taken by the infamous Christopher Lee the week of June 6th, 2005.

Friday, June 10, 2005

Texas Chainsaw Massacre - KILLER FOUND!

Canada! Who knew!

Massachusetts lawmakers on Thursday called for a closer look at border security after customs officials allowed a man carrying a sword, a hatchet, brass knuckles and a chain saw stained with what appeared to be blood to cross the U.S.-Canadian border.


Tuesday, June 07, 2005

Court Says Gay Man Can Drive

Kymrbrla's Note: It is unbelievable that this story is from 2005. Seems like it would be from year 1705.

Rome, Italy

A Sicilian court condemned road authorities Monday for suspending the driving license of a man after finding out he was gay.

The court on the Mediterranean island said being gay was merely "a personality disturbance" which had no bearing on a person's ability to drive, Ansa news agency reported.

The 23-year-old man, who was identified as Danilo G., got into trouble with the road license authorities in the city of Catania after they discovered he had been exempted from military service because he was gay.

The authorities suspended his driving license ahead of further checks on his "suitability" to take the wheel.

The man's lawyer, Giuseppe Lipera, denounced the move as "utterly scandalous and offensive" and has demanded 500,000 euros ($613,500) in damages.

"Danilo ... is deeply perturbed by what has happened. He has lost his hair and is suffering shock," Lipera was quoted as saying by Ansa.

In a written ruling released Monday, the Sicilian court said: "It is clear that sexual preferences do not in any way influence a person's ability to drive motor cars safely."

The judges added that homosexuality "cannot be considered a true and proper psychiatric illness, being a mere personality disturbance."

Homosexuality is legal in Italy, but openly anti-gay comments from politicians and officials rarely cause a stir.

Friday, June 03, 2005

Hey! Isn't that Dad up on that billboard?

People who solicit prostitutes in Oakland, California, could find their faces plastered on billboards under a new shaming program that one civil rights group calls bad public policy.

The city of 400,000 across the bay from San Francisco started putting up billboards on Wednesday showing men arrested for soliciting sex. Other signs invite prostitutes to quit by calling a help line.

"This idea came out of just thinking about new ideas, doing something to deal with this increasing problem, especially with the exploitation of underage women," said Oakland City Council President Ignacio De La Fuente, who champions the approach.

The photos on the billboards were partially blurred so the men are not easily identifiable. But in the future photos might be displayed unaltered, an aide to De La Fuente said.

Critics say the technique -- which De La Fuente said has been used in Texas -- recalls medieval public humiliations.

"It doesn't seem to us to be appropriate for Oakland to be using shaming as an additional and extrajudicial punishment to single out this group of offenders," said Alan Schlosser, legal director of the American Civil Liberties Union for Northern California. "We don't think this is good public policy."

Some newspapers have long printed the names of those soliciting sex for money, and courts have backed punishments that include shaming. Last year a U.S. federal appeals court allowed a punishment in which a mail thief had to wear a signboard telling of his crime.

Wednesday, June 01, 2005

Multiple Myeloma and SCIO-469

By Denise Gellene Times Staff Writer
Wed Jun 1, 7:55 AM ET

Michael Crockett rushed through the door at the Sunnyvale, Calif., laboratory of Scios Inc. toting an Igloo cooler. Packed inside, beneath a layer of ice, was a vial of human bone marrow.

The marrow was needed to test a tantalizing hypothesis: that Scios' experimental rheumatoid arthritis pill, SCIO-469, might also treat cancer. As Crockett, manager of the company's drug projects, delivered the bone marrow to Scios researchers in February 2003, he knew there was more at stake than product development.

His boss, Scios Chief Executive Richard B. Brewer, donated the marrow. Brewer had multiple myeloma, an incurable blood cancer that might be helped by the company's pill.

The theory at the firm was that the drug might prevent malignant cells from multiplying, maybe one day turning myeloma into a manageable illness, like diabetes.

But scientists had to work fast. The firm's board of directors was preparing to sell the unprofitable biotech to drug giant Johnson & Johnson. And there were no guarantees that the SCIO-469 cancer project would continue under new ownership. J&J saw enormous potential in SCIO-469 — perhaps a billion dollars a year — but as a pill for rheumatoid arthritis.

Brewer hoped to persuade his new bosses to also test the pill in cancer patients. Most of the drugs he had used to treat his cancer were old and harsh; one chemo drug had wiped out all feeling in his feet. He became ill and his hair fell out.

"I'm hoping [other patients] won't have to go through what I went through," Brewer said.

Those at Scios who had watched Brewer battle his illness believed they were on a mission.

"When someone you know and respect gets a disease, you get angry," said Scios' top scientist, George F. Schreiner. "We hated myeloma…. We wanted to tear it down, plow it under the ground and put enough salt in so it never comes back."

Brewer, now 54, became CEO of Scios in 1998. He began his career in biotech at Genentech Inc. where he had led the product team that launched human growth hormone, Genentech's first drug. He rapidly rose to head of sales and marketing, helping to transform Genentech into an industry giant, while becoming known as a hands-on executive willing to take risks.

A top priority at Scios — from the Greek word scionoso meaning "to know" — was developing a drug to neutralize p38, an enzyme believed to spur inflammation in rheumatoid arthritis patients. There were few effective drugs for the joint disease, which affected 1 million Americans, making it a lucrative market.

Using sophisticated computer programs, Scios researchers designed molecules that looked like they might block the activity of p38, and neutralize it. Guided by the computer models, chemists then mixed one compound after another in search of a usable drug.

As Scios scientists closed in on their goal, they began to hear the footsteps of big pharmaceutical firms working on similar pills. Every day there were rumors that a bigger competitor had leaped ahead. Then, just as suddenly, GlaxoSmithKline, Merck & Co. and others had setbacks, leaving Scios in the lead.

By the end of 2000, Scios was ready to test its pill in patients with rheumatoid arthritis.

Meanwhile, Brewer faced his own struggle. The first sign of trouble came in May 2000, when Brewer felt a twinge in his back. At first, he thought he had strained a muscle when he loaded his dog, a 70-pound boxer, into the back of his SUV. But the pain worsened, so Brewer went to a doctor, who told him he had a compressed disk.

His condition didn't improve with rest. By spring 2001, Brewer could not stand upright and had to sleep in a chair to avoid intense pain.

Brewer kept up a grueling schedule, which was also taking its toll. The company was on the verge of receiving long-awaited federal approval of its first product — an intravenous medicine for congestive heart failure patients — and important meetings were scheduled with the Food and Drug Administration.

Brewer steadily lost weight and the pain got worse, despite visits to a chiropractor. Aspirin didn't help. Damage to his spine had shaved an inch off his 6-foot 4-inch height.

The scientists on Scios' executive team were alarmed by their boss' worsening condition. Chief Medical Officer Darlene Horton, a physician, feared she was watching Brewer die. She warned him that he might have cancer.

"This is not normal back pain," Horton recalled telling him. "You don't need massages, you don't need a chiropractor. You need an MRI — now." But Brewer told her his bone scans, another sort of imaging test, showed no sign of disease.

Finally, at the recommendation of his doctor, Brewer had a surgeon inject plastic into his spine to cushion the damaged disk. During the procedure, the surgeon took a bone marrow biopsy.

Driving to work days later, Brewer took a call from his doctor on his cellphone. The executive learned he had myeloma, a cancer he had never heard of. The disease destroys plasma cells, which produce antibodies and are found in bone marrow, the soft tissue inside bones. Nearly two-thirds of Brewer's marrow was malignant. Without treatment, he would be dead in a year.

In late summer 2001, Brewer started high doses of chemotherapy at City of Hope National Medical Center in Duarte. Every two weeks, doctors loaded drugs into his body through a catheter implanted in his chest. He lost weight and went bald.

Six months later, he underwent a risky bone marrow transplant to restore damaged tissue. Brewer recalled long days in his hospital bed, wired to pumps and monitors, too sick and exhausted to watch TV. He marked time by observing shadows march across his room as the sunlight in his window faded.

"It was the worst experience I could have imagined," he said. "Every cell in your body has been turned upside down and backwards. It changes you."

Brewer was back at work in April 2002. His cancer was in remission, but because myeloma is incurable, Brewer did not know how long he would remain cancer-free. His doctor at City of Hope, Stephen Forman, said remissions could last more than five years, or as little as one.

Though tired and thin, Brewer plunged into looking for a deep-pocketed drug company to help Scios develop its arthritis pill. Large clinical trials needed to test arthritis drugs were expensive, and the small company did not have the resources to complete the work on its own.

Through the spring and fall, big drug companies came calling. Brewer had hoped to license rights to the pill, but negotiations took a sharp turn. By mid-December, two firms, including Johnson & Johnson, said they wanted to buy Scios. With Scios' permission, the suitors started reviewing confidential documents in preparation for a bid.

Then, in January 2003, Brewer spotted an article in a newsletter about a study that linked the p38 enzyme — the target of SCIO-469 — to myeloma. The researcher was Kenneth Anderson of the Dana-Farber Cancer Institute in Boston, an authority on the disease.

Brewer contacted Anderson, who was surprised by the call. He was used to hearing from industry scientists but seldom talked shop with CEOs. He explained to Brewer that p38 releases chemicals that spur the growth of cancerous myeloma cells. In theory, if a drug blocks p38, the tumor can't survive. Brewer turned the article over to one of his top researchers, Linda Higgins, and asked her to dig deeper. The assignment made her nervous at first.

"I was worried I would have to deliver disappointing or equivocal news," she said. "There was nothing in the literature connecting these dots except Ken Anderson's work."

But after a week of intense research, Higgins told her boss: "I think we have a shot."

Elated, Brewer told his wife, Debbie. The couple, now divorced, had struggled to find a meaning in Brewer's illness. Brewer had immersed himself in books about spirituality and healing, and at one point consulted what he called a "life coach." All the while, a potential treatment for Brewer's illness was in his company's lab.

"My God, Dick," Debbie told him, becoming tearful as she recalled the moment. "Maybe this was why. You were meant to develop this drug."

Brewer shared her sense of destiny. If successful, SCIO-469 might help patients like himself while sparing them chemotherapy treatments.

"It was providential," Brewer said. "Unless you believe that things just happen randomly — but I don't."

Higgins needed healthy cells from human bone marrow for her experiments, so Brewer volunteered. The first anniversary of Brewer's bone marrow transplant was approaching, and he was scheduled for a full day of medical tests at City of Hope. The CEO arranged to have marrow taken for Scios at the hospital.

In early February 2003, as acquisition talks heated up, Brewer went to City of Hope, accompanied by Crockett, who toted the red-and-white cooler. Brewer's wife and son also made the trip.

As the CEO waited between tests, he worked his cellphone, trading calls with lawyers and Scios directors about J&J, which had become the front-runner. Then, during a physical exam, a physician used a long needle to extract marrow from Brewer's pelvic bone. He squeezed some of the pinkish tissue into a vial and packed it in the ice-filled cooler.

A short time later, just past 6 p.m., Brewer emerged from the examination room and handed the cooler containing his marrow to Crockett.

Before leaving the hospital, Brewer received welcome news: His cancer had not returned. Brewer, his family and Crockett had a celebratory steak dinner at a nearby restaurant, and, because it was late, spent the night at a hotel. The cooler was always in Crockett's reach. It was under his feet as he dined and near his bed as he slept.

Early the next morning, they flew aboard a private jet from Burbank to San Francisco. A driver whisked Crockett from the airport to Scios, where Higgins was waiting for him. It was about 9 a.m.

Because cells begin to die as soon as they leave the body, Higgins had to work quickly. "We were stretching the envelope," she said.

Higgins isolated very specific cells, called stromal cells, from Brewer's tissue. In healthy people, stromal cells form the scaffolding that supports the blood-forming cells in the marrow. In patients with myeloma, stromal cells become "brainwashed" by cancerous plasma cells to produce nourishing chemicals, called cytokines.

While stromal cells do the bidding of cancer cells, they remain healthy and don't become malignant.

Under a microscope, Brewer's cells were translucent specks against a background of pale yellow and pink. They looked healthy — good news, because Higgins needed to incubate them so she would have many cells available to test SCIO-469.

Higgins took a photograph of the cells and e-mailed a copy to Brewer because she knew he would want to see them.

"It was eerie," he recalled. "I had never seen my cells before. And to think they had been attacked … "

Brewer and Higgins code-named the cells 103TK, a twist on the tail number of the CEO's private aircraft. Higgins didn't want her team to have the added pressure of knowing they were experimenting on the boss' tissue.

Four days after his trip to City of Hope, Brewer voted with the rest of Scios' directors to accept a $2.4-billion offer for the company from J&J.

Brewer had not wanted to sell the company. Scios, after a decade of disappointment, had finally tasted success. Its heart drug had been approved, and the company appeared close to potential breakthroughs in arthritis and cancer. But as a director accountable to shareholders, Brewer said he could not turn down J&J's offer.

During negotiations with J&J, Brewer made a case for continuing the myeloma project after the merger. To J&J pharmaceutical group president Joseph Scodari, the research sounded plausible, but sketchy.

"It was obvious to us that Dick not only saw this as a business opportunity but had a great personal interest in this," he recalled.

Brewer knew the transition to new ownership would take several months, time Scios could use to build a case for the drug. "We decided to go full blast," Brewer said.

One of his first steps was to recruit expert advisors, including Anderson of the Dana-Farber institute. Anderson flew to California in late February and came away impressed with the small company's science and inspired by its CEO.

"The circumstances that brought us together were very rare," Anderson said. "One has to believe there must be a reason."

Still, many at Scios worried about scientists at the company losing objectivity on a project so dear to them — and their CEO. So the myeloma team held open forums, allowing other scientists to grill them. Brewer resolved to stay out of his scientists' way. "I didn't want anyone feeling guilty that if they didn't do something, the CEO was going to be unhappy," he said.

Higgins wrote a detailed plan to test SCIO-469. She coaxed the healthy stromal cells from Brewer's marrow to secrete the chemicals that fed tumors. Then she added SCIO-469 to the mix. With a team of junior scientists, Higgins repeated each step three times with the same encouraging result: The flow of nourishing chemicals slowed.

Much work remained before the pill would be ready to test in cancer patients.

Scios senior managers, meanwhile, started integration meetings with J&J representatives to set new corporate priorities. All projects were reexamined. A drug factory planned by Scios was axed because it was no longer needed. Some responsibility for SCIO-469 in arthritis was shifted to a J&J unit in Pennsylvania, which already sold a rheumatoid arthritis drug.

The cancer project "was constantly under review," Brewer recalled.

Higgins' team worked late, often past 9 p.m. It wasn't unusual for Higgins to arrive in her lab at 3:30 a.m. on Sundays; she put in a few hours before going home for breakfast with her two preteen children.

"At the end of every day, seven days a week, I'd ask myself the same question: Why can't I go faster?" she said.

Brewer touted the project at every opportunity. "Dick really kept J&J focused on myeloma as something worth pursuing," said Crockett, who attended integration meetings. "They all knew Dick's situation, but we weren't doing it just because Dick had the disease. We had experts telling us to continue."

At a gathering of top J&J executives in Orlando, Fla., in May 2003, Brewer outlined all of Scios' drug development projects. Included were data generated by Higgins' team. The studies impressed J&J, which allocated funds to continue the experiments.

"The science made sense and the business opportunity was significant," Scodari said later.

By mid-June 2003, Higgins completed her work. Thirty people — Scios scientists, their academic advisors and representatives of J&J — gathered at a hotel in Half Moon Bay, Calif., to review all the data. Higgins told the group that myeloma cells in a lab dish became weaker when SCIO-469 was added. The healthy stromal cells were unharmed.

At one point, Crockett drew the room shades and shut out the ocean view to keep the group focused. Higgins' work suggested that long-term use of SCIO-469 would lead to the death of myeloma cells. At the very least, the experts believed, the pill would spare patients the severe bone pain and damage that Brewer had experienced.

By the end of the meeting, the experts had devised a plan for testing SCIO-469 in cancer patients. "That is when our p38 inhibitor became a full development oncology project," Crockett said.

Several dozen cancer patients have taken SCIO-469 as part of a clinical trial, scheduled to end by early summer. They took the pill alone for a while, then in combination with a cancer drug called Velcade, which J&J shares the rights to market. If the results are promising, Scios plans a bigger test with more patients.

Today, three years after his bone marrow transplant, Brewer remains in remission. He is fortunate. Statistics show that more than half of myeloma patients are dead within five years of diagnosis.

Brewer is not in the clear, however, and his treatments haven't ended: He receives regular infusions of a drug to rebuild his bones.

Brewer resigned from Scios in February, in a mock graduation ceremony at the company's headquarters, now located in Fremont, Calif. A large screen in the auditorium flashed photos of his dog, his family and Brewer, first as a businessman, then as a patient tethered to an intravenous line.

The transition was complete. "We had a great staff here…. It was quite an experience," he said after the ceremony, wearing his blue cap and gown and clutching his farewell gift: a white lab coat with his name embroidered on it.

Brewer now advises start-up drug companies and sits on some biotech company boards. As an outsider — and a myeloma patient — he is eagerly awaiting clinical trial results for SCIO-469.

"What I am hoping is that patients will be able to take two pills a day and live with their cancer," he said. "That would be Valhalla for us."